Author/Authors :
Rajavi, Zhale Shahid Beheshti University of Medical Sciences, Tehran , Safi, Sare Shahid Beheshti University of Medical Sciences, Tehran , Javadi, Mohammad Ali Shahid Beheshti University of Medical Sciences, Tehran , Jafarinasab, Mohammad Reza Shahid Beheshti University of Medical Sciences, Tehran , Feizi, Sepehr Shahid Beheshti University of Medical Sciences, Tehran , Sedighi Moghadam, Mohammadreza Janbazan Medical and Engineering Research Center, Tehran , Jadidi, Khosrow Baqiyatallah University of Medical Sciences, Tehran , Babaei, Mahmoud Baqiyatallah University of Medical Sciences, Tehran , Shirvani, Armin Ministry of Health and Medical Education, Tehran , Baradaran-Rafii, Alireza Department of Ophthalmology - Labbafinejad Medical Center - Shahid Beheshti University of Medical Sciences, Tehran , Mohammad-Rabei, Hossein Department of Ophthalmology - Torfeh Hospital - Shahid Beheshti University of Medical Sciences, Tehran , Ziaei, Hossein Shahid Beheshti University of Medical Sciences, Tehran , Ghassemi-Broumand, Mohammad Department of Optometry - School of Rehabilitation - Shahid Beheshti University of Medical Sciences, Tehran , Delfaza Baher, Siamak Department of Ophthalmology - Torfeh Hospital - Shahid Beheshti University of Medical Sciences, Tehran , Naderi, Mostafa Baqiyatallah University of Medical Sciences, Tehran , Panahi-Bazaz, Mahmoodreza Department of Ophthalmology - Ahvaz Jundishapur University of Medical Sciences, Ahvaz , Zarei-Ghanavati, Siamak Department of Ophthalmology - Mashhad University of Medical Sciences, Mashhad , Hanjani, Shahriar Department Research and Development - Parsian Clinic of Ophthalmology, Isfahan , Ghasemi, Hassan Department of Ophthalmology - Shahed University, Tehran , Salouti, Ramin Department of Ophthalmology - Shiraz University of Medical Sciences, Tehran , Pakbin, Mojgan Shahid Beheshti University of Medical Sciences, Tehran , Kheiri, Bahareh Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
Purpose: To develop clinical practice guidelines (CPGs) for prevention, diagnosis, treatment and follow-up of
ocular injuries caused by exposure to mustard gas.
Methods: The clinical questions were designed
by the guideline team. Websites and databases
including National Guidelines Clearinghouse,
National Institute for Clinical Excellence, Cochrane,
and PubMed were searched to find related CPGs
and explore possible answers to the clinical
questions. Since there were no relevant CPGs in the
literature, related articles in Persian and English
languages were extracted. Each article along with its level of evidence was summarized. Additionally, hand search was performed by looking the reference list
of each article. Consequently, recommendations were developed considering the clinical benefits and side
effects of each therapeutic modality. The recommendations were re‑evaluated in terms of customization criteria.
All recommendations along with the related evidence were scored from 1 to 9 by experts from all medical
universities of Iran. The level of agreement among the experts was evaluated by analyzing the given scores.
Results: The agreement was achieved for all recommendations. The experts suggested a number of
minor modifications which were applied to the recommendations. Finally, CPGs were developed with 98
recommendations under three major domains including prevention of injury, diagnosis and management
of the acute and delayed‑onset mustard gas ocular injuries.
Conclusion: Considering the lack of CPGs for the prevention, diagnosis, and management of mustard
gas‑induced keratitis, these recommendations would be useful to prevent the serious ocular complications
of mustard gas and standardize eye care services to the affected individuals.
