Title of article :
Vitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats
Author/Authors :
Allahtavakoli, Mohammad Department of Physiology - School of Medicine - Rafsanjan University of Medical Sciences, Rafsanjan , Pourshanazari , Aliasghar Department of Physiology - School of Medicine - Rafsanjan University of Medical Sciences, Rafsanjan , Heshmatian, Behnam Department of Physiology - School of Medicine - West Azarbaeejan University of Medical Sciences, Oroomiah
Abstract :
Objective(s)
Previous studies have demonstrated that pretreatment with alpha-tocotrienol (α-TCT) can reduce ischemic
damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease strokedependent
brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present
study, the neuroprotective effects of α-TCT and rosiglitazone (RGZ) at 3 hr after cerebral ischemia were
investigated.
Materials and Methods
Stroke was induced by embolizing a preformed clot into the MCA. Rats were assigned to vehicle, α-TCT
(1 or 10 mg/kg), RGZ and sham-operation.
Results
Compared to the control group, only RGZ decreased infarct volume (P<0.05), neurological deficits (P<0.05)
and sensory impairments (P<0.01) but low and high doses of α-TCT did not show any significant
neuroprotective effect.
Conclusion
Our data showed that α-TCT was not neuroprotective at 3 hr after the embolic model of stroke. Further
studies should be undertaken to clarify the neuroprotective effects of α-TCT after stroke.
Keywords :
Vitamin E , Neuroprotection , Embolic model , Cerebral ischemia , Alpha-tocotrienol
Journal title :
Astroparticle Physics
