Author/Authors :
Emami, Seyed Ahmad Department of Pharmacognosy - School of Pharmacy - Mashhad University of Medical Sciences, Mashhad , Tayarani-Najaran, Zahra Department of Pharmacology and Pharmacological Research Centre of Medicinal Plants - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Sabouri Ghannad, Masoud Department of Microbiology - Faculty of Medicine - Hamadan University of Medical Sciences, Hamadan , Khajeh Karamadini, Pezhman Department of Microbiology - Faculty of Medicine - Hamadan University of Medical Sciences, Hamadan , Khajeh Karamadini, Mehrangiz Department of Microbiology - Quaem Medical Center - Mashhad University of Medical Sciences, Mashhad
Abstract :
Objective(s)
The aim of this study was to search for new antiviral agents from herbal medicines. Ethanol extracts of
C. semipervirens, C. semipervirens var. horizontalis and C. semipervirens cv. Cereiformis were used in
experiments to test their influence on herpes viruses (HSV-1).
Materials and Methods
HeLa cells monolayers were infected with herpes viruses (HSV-1). Antiviral activity of the plant extracts
assessed using Hematoxylin & Eosin method and observed under a light microscope. All tests were
compared with a positive control, acyclovir.
Results
Results showed that all three plants have antiviral activity against HSV-1 virus. The most active extract was
the obtained extract from C. semipervirens. Among the different parts of this medicinal plant tested, the
fruit’s extract appeared to possess the strongest anti- HSV activity.
Conclusion
In conclusion, of the extracts tested in this survey all showed significant antiviral potency.
Keywords :
HSV-1 , Cupressusaceae , Cupressus sempervirens , Antiviral activity
