Rose Bengal-Green Light for Collagen Cross‑linking

Wollensak et al reported the first application of corneal cross‑linking (CXL) for the treatment of keratoconus in 2003.[1] Thereafter, many articles were published regarding the efficacy of CXL to halt the progression of keratoconus. Long‑term studies have shown its success rate ranging from 78% to 100%.[2,3] Two studies evaluated the effect of CXL on decreasing the number for keratoplasty procedures in patients with keratoconus. Dutch Transplant Registry showed a significant decrease in the need for keratoplasty after implementation of CXL.[4] Another study showed that the need of keratoplasty for keratoconus is halved mostly due to the effect of CXL.