Title of article :
The Role of Mitochondria in AMD: Current Knowledge and Future Applications
Author/Authors :
Riazi‑Esfahani, Mohammad Department of Ophthalmology - Gavin Herbert Eye Institute - University of California Irvine - Irvine - California, USA , Kuppermann, Baruch D Department of Ophthalmology - Gavin Herbert Eye Institute - University of California Irvine - Irvine - California, USA , Kenney, M. Cristina Department of Ophthalmology - Gavin Herbert Eye Institute - University of California Irvine - Irvine - California, USA
Abstract :
Mitochondria are organelles which comprise the main respiratory machinery in the eukaryotic cells. In
addition to their crucial role in energy production, they have profound effects on apoptosis and retrograde
signaling to nucleus. Mitochondria have their own DNA, which codes for different proteins mostly involved
in oxidative phosphorylation. Significant changes in the mitochondria of retinal pigment epithelium have
been reported in age‑related macular degeneration (AMD), which is correlated with the severity of the
disease. Cybrid cell lines that have identical nuclei but mitochondria from different individuals can provide
a unique means for studying the relationship between mitochondria and AMD. Different approaches for
protection of mitochondria have been introduced which can be considered as potential future treatments
for AMD and other age‑ related disorders.
Keywords :
Age-related Macular Degeneration , DNA , Mitochondria , Mitochondrial
Journal title :
Astroparticle Physics
