Author/Authors :
Mousavizadeh, Kazem Department of Molecular Biology - Cellular and Molecular Research Center, Tehran , Askari, Mohammad Department of Biotechnology - College of Allied Medicine, Tehran , Arian, Hajar Department of Medical Genetic - Special Medical Center, Tehran , Gourjipour, Fazel Department of Molecular Biology - HIV Molecular Research Laboratory - School of Public Health and Health Research Institute - Tehran University of Medical Sciences, Tehran , Nikpour, Amin R Department of Immunology - Kerman University of Medical Sciences, Kerman , Tavafjadid, Maryam Department of Molecular Biology - Cellular and Molecular Research Center, Tehran , Aryani, Omid Department of Medical Genetic - Special Medical Center, Tehran , Kamalidehghan, Behnam Department of Pharmacy - Faculty of Medicine - University of Malaya - Kuala Lumpur, Malaysia , Maroof, Hamid R Department of Medical Genetic - Special Medical Center, Tehran , Houshmand, Massoud Department of Medical Genetic - Special Medical Center, Tehran
Abstract :
Autism spectrum disorders (ASD) are the most heritable
complex disorders.[1,2] Although there have been many
efforts to locate the genes associated with ASD risk, the
genetics of ASD has not been elucidated.[3-5] Some studies
have confirmed the contribution of mitochondrial
genome mutations to the pathophysiology of autism,[4,6]
but other studies have rejected such a contribution.[7] In
the current study (research project number #17), we have
investigated the association between mitochondrial
tRNA gene mutations and the risk of autism.
