Author/Authors :
Fan, He-Bin Departments of Infectious Disease - Huazhong University of Science and Technology - Wuhan - Hubei Province, China , Yang, Dong-Liang Department of infectious diseases - union Hospital of Tongji Medical College - Huazhong University of Science and Technology - Wuhan - Hubei Province, China , Guo, Yong The People’s Liberation Army 161 Hospital - Huazhong University of Science and Technology - Wuhan - Hubei Province, China , Chen, An-Shen Departments of Infectious Disease - Huazhong University of Science and Technology - Wuhan - Hubei Province, China , Zhou, Mu-Xiu The People’s Liberation Army 161 Hospital - Huazhong University of Science and Technology - Wuhan - Hubei Province, China , Wu, Juan-Juan Departments of Infectious Disease - Huazhong University of Science and Technology - Wuhan - Hubei Province, China , Ma, Xiao-Ju The People’s Liberation Army 161 Hospital - Huazhong University of Science and Technology - Wuhan - Hubei Province, China , Li, Zhi Departments of Infectious Disease - Huazhong University of Science and Technology - Wuhan - Hubei Province, China
Abstract :
Th is study describes a rare case of Human Immunodefi ciency Virus and Human Herpes Virus 8 (HHV-8) negative primary eff usion
lymphoma (PEL)-like lymphoma in a patient with hepatitis B virus-related liver cirrhosis, diagnosed in a 66-year-old male who
rapidly progressed to a sense of abdominal fullness. Cytological analysis of the pleural eff usion demonstrated large atypical lymphoid
cells with rounded nuclei, prominent nucleoli, and abundant cytoplasm. Immunocytochemistry of the pleural eff usion detected
atypical CD20+ lymphoid cells. Th e patient was hospitalized, and died following sepsis and multi-organ failure. Our case highlights
that HHV-8-unrelated PEL-like lymphoma patients have diff erent pathogenetic mechanisms of causality at the biological level,
immunophenotype, clinical behavior, and prognosis.
Keywords :
Hepatitis B virus , human herpes virus 8 , liver cirrhosis , primary eff usion lymphoma
