Author/Authors :
Moini, Ashraf Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center - Royan Institute for Reproductive Biomedicine - ACECR, Tehran , Hosseini, Reihaneh Department of Gynecology and Obstetrics - Arash Women’s Health Hospital - Tehran University of Medical Sciences, Tehran , Jahangiri, Nadia Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center - Royan Institute for Reproductive Biomedicine - ACECR, Tehran , Shiva, Marzieh Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center - Royan Institute for Reproductive Biomedicine - ACECR, Tehran , Akhoond, Mohammad Reza Department of Statistics - Faculty of Mathematical Science and Computer - Shahid Chamran University, Ahwaz
Abstract :
Background: Ectopic pregnancy (EP) is a condition presenting as a major health problem for women of childbearing age.
This study aimed to identify potential risk factors for EP and to evaluate the contribution of the risk factors associated to EP.
Materials and Methods: This retrospective nested case–control study was conducted from 2006 to 2011. In case group, there were
a total of 83 women diagnosed with EP, while in the control group; there was a total of 340 women who gave birth. The basic recorded
information included surgical, gynecological, obstetrics, sexual, contraceptive, and infectious histories; demographic characteristics;
smoking habits; fertility markers; as well as reproductive outcome after EP. The association between EP and the factors studied was
analyzed by logistic regression. Results: The findings reveal that the following factors were associated with increased risk of EP,
including: Maternal age (odds ratio [OR] =1.11, confidence interval [CI] [1.06–1.16], P < 0.0001), spouse’s cigarette smoking (OR = 1.73,
CI [1.05–2.85], P = 0.02), gravidity (OR = 1.50, CI [1.25–1.80], P < 0.0001), prior spontaneous abortions (OR = 1.93, CI [1.11–3.36],
P = 0.01), history of EP (OR = 17.16, CI [1.89–155.67], P = 0.01), tubal blockage (OR = 10.85, CI [2.02–58.08], P = 0.01), use
of intrauterine device (IUD) (OR = 4.39, CI [1.78–10.81], P = 0.001), tubal damage (OR = 2.704, CI [1.26–5.78], P = 0.01), first
pregnancy interval (OR = 1.01, CI [1.00–1.02], P < 0.0001) and history of infertility (OR = 6.13, CI [2.70–13.93], P < 0.0001).
Conclusion: By identifying risk factors being amenable to modification, such as cigarette smoking and use of IUD and first pregnancy
interval the effective risk‑reduction strategies can be devised.
