Effect of Ketofol instead of Propofol on hemodynamic stabilization for induction of anesthesia in laparatomy

Background: Hemodynamic alterations are a common complication during anesthetic induction with intravenous anesthesia. Hypotension due to propofol injection may be very severe in cardiac vascular patients. Ketamine produces increasing significantly, but temporary effect on systematic blood stream, heartbeat, and cardiac output through central sympathetic stimulation. The aim of the study was to determine effect of ketofol and propofol for induction of anesthesia on hemodynamic changes during induction of anesthesia. Materials and Methods: In the randomized clinical trial study, 96 patients who were candidate for laparotomy enrolled and divided into two random groups of propofol (48 person) and ketofol (48 person). Hemodynamic changes were recorded and examined after induction for 5 and 10 minutes after intubation. Results: Heart rate was significantly variable in propofol group compared to ketofol group. Systolic, diastolic, and mean arterial blood pressure was not significantly changed during the time period of recording in ketofol group. However, blood pressure was significantly changed during the study in the propofol group. Conclusion: ketofol is a proper alternative to propofol to stabilize heart rate and blood pressure in laparotomy.