Mathematical modeling for hemoglobin change due to blood loss due to hookworm infection

Hookworm is an important tropical infection that can result in blood loss and hypochromic microcytic anemia. The pathophysiology of blood loss due to hookworm infection is very interesting. Here, the authors try to use the medical mathematical modeling for the explanation of the blood loss due to hookworm infection. Basically, the normal hemoglobin level is physiologically maintained, and the normal red blood cell pool in blood is physiological observed. This can be represented as “red blood cell pool = red blood cell production – red blood cell destruction” or “hemoglobin pool = hemoglobin production – hemoglobin destruction.” The turnaround time of red blood cell or red blood cell lifespan is 120 days or 4 months or estimated 3 g/dL of hemoglobin decrease at 1 month. At this physiological level, the stabilizing can be seen.