Methylenetetrahydrofo late reductase C677T polymorphism and schizophrenia: Effect of molecular change

Schizophrenia is an important psychological disorder. There are many reports on the underlying medical and genetic underlying factors of schizophrenia. Malhotra et al. recently noted that “there is some evidence to suggest an association of MetS with adiponectin levels, hematological indices, methylenetetrahydrofolate reductase (MTHFR), and Alpha‑1A adrenergic receptor gene.[1]” Focusing on MTHFR, Yadav et al. performed meta‑analysis study and suggested that “the MTHFR C677T polymorphism is a risk factor for schizophrenia.[2]” Here, the authors would like to discuss on the effect of MTHFR C677T polymorphism based on basic consideration on nanomolecular weight change. Theoretically, the molecule with polymorphism will have altered molecular weight that might affect the biological process.