Author/Authors :
Niyakan, M Department of Biology - Kazerun Branch, Islamic Azad University, Kazerun, Iran , Akbarpour, B Department of Physiology - Faculty of Veterinary Medicine - Kazerun Branch, Islamic Azad University, Kazerun, Iran , Khoshvaghti, A Department of Clinical Sciences - Faculty of Veterinary Medicine - Kazerun Branch, Islamic Azad University, Kazerun, Iran
Abstract :
Of the nine chemical compounds identified in the Carum Copticum extract, thymol, γ-terpinen, and
parasaymn are considered as the main compounds utilized as antiemetic, anti-asthma, anti-nausea, and spasmodic,
locally used in the treatment of rheumatic pains with therapeutic effects on skin diseases, mental disorders, and
genitourinary diseases. The recent scientific studies have confirmed the antiseptic impact and decreasing effects of
blood cholesterol in this plant. For the purpose of this study, 72 male Wistar rats were divided into 6 groups as
control, sham, and experimental groups (1 to 4). While the control group received no treatment, sham group
received 2/0 ml of distilled water and experimental groups (1 to 4) took daily 200, 400, 600 and 800 mg /kg aqueous
extract of C. copticum as intraperitoneal injection, respectively. After a lapse of 16 and 32 days, rats’ blood samples
were taken. The kidneys, belonging to rats died during blood sampling after day 16 and the rats remained alive after
the day 32, were removed and their uric acid and renal histology were examined. The collected data then were
analyzed using SPSS statistical software package. In this study, statistical tests such as one way ANOVA, and post
hoc Duncan were carried out. P-value of less than 0.05 was regarded as statistically significant (p<0.05). The
findings revealed that the use of aqueous extract of C. copticum in a low dose and short and long terms results in a
body weight loss and with a moderate and high dose only in long term leads to a body weight loss. Regardless of
the dose, the use of such extract in short and long terms increases the kidney function. In all groups, the kidney
tissue in short and long terms was completely normal with no damage. As a conclusion, this study demonstrates that
the use of C. copticum extract, with no adverse effect on renal tissue, causes an increase in kidney function, though
the effects of these extracts will be somehow different in details in short and long terms.
