Botulinum toxin-A injections in children with neurogenic bladder

Background: Botulinum-A toxin (BTX) administration appears to be useful in patients with high pressure neurogenic bladder. Objectives: The aim of this study was to evaluate the usefulness of cystoscopic injections of BTX in the detrusor wall in the treatment of children with overactive neurogenic bladder dysfunctions. Patients and Methods: The prospective, non-placebo controlled study was conducted with the approval of Local Ethics Committee. The study group consisted of 31 girls and 34 boys with neurogenic bladder overactivity, aged from 1 to 14 and treated with Botulinum-A toxin (Dysport, Ipsen). Results: Both values of volumes of the catheterized urine and bladder volumes in urodynamic studies increased significantly after the therapy and it proved that the younger patient the more effective the percentage of volumes growth. Conclusion: The results showed that endoscopic administration of BTX improved functional parameters of urinary bladder in cases of children with neurogenic bladder and the method might represent an alternative approach to operative reduction of intravesical pressures.