Effect of Erdosteine on Cyclosporine Induced Chronic Nephrotoxicity

Drugs and exogenous toxins, including aminoglycosides, amphotericin B, cisplatin, and radiocontrast media, may cause acute kidney injury (1). The manifestations which indicate that damage is occurring are a sudden increase in kidney injury biomarkers (NGAl [neutrophil gelatinase-associated lipocalin], KIM-1 [kidney injury molecule-1], etc.) and kidney failure (creatinine, cystatin C). This implies a requirement for close monitoring of kidney function with eventual dose reduction or even the interruption of drug administration. however, it may eventuate that, even if the source of the damage is stopped, it could still result in permanent kidney failure. one of the major causes of kidney injury driven by different compounds is an increase in the production of reactive oxygen species (RoS), activation of stress kinases and thus apoptosis (2, 3).