A commentary on: Does Living Donor Hyperoxia Have an Impact on Kidney Graft Function After Transplantation

I read with great interest the valuable article entitled “Does living donor hyperoxia have an impact on kidney graft function after transplantation?” written by Dr. Rostami et al. (1). In this project, the authors have showed the effect of living donor oxygen therapy on function of grafted kidneys in recipients and for better comparison they’ve used a control group. Moreover, they also have assessed kidney function with some sound biomarkers such as neutrophil gelatinase-associated lipocalin, interleukin-18, and tumor necrosis factor-α that can be used for early diagnosis of kidney injury. Finally, they concluded that normobaric hyperoxia of living donors before kidney transplantation had no effect on kidney function in renal transplant recipients and suggested more studies in this field. There are only a few studies that investigated this effect in human (2-4) and I appreciate the admirable effort by authors for conducting this study; however, it seems that there are some remarks in their work that I want to point them out respectfully.