Title of article
Vaccination of Tamarin with Recombinant Vaccinia Virus Expressing Epstein Barr Virus (EBV) Latent Proteins
Author/Authors
Mahmoodian Shooshtari, Mahmood , Finerty, Suzan Departments of Pathology and Microbiology - University of Bristol - Bristol, U.K , Morgan, Andrew John Departments of Pathology and Microbiology - University of Bristol - Bristol, U.K
Pages
5
From page
71
To page
75
Abstract
The aim of this work was to see whether tamarin immunisation with recombinant
vaccinia virus expressing Epstein Barr Virus latent proteins could prime T cells which
were, on activation, able to inhibit the outgrowth of Epstein Barr virus transformed
cells in vitro.
The vaccination appeared to be successful as all vaccinated tamarins developed
vaccinia lesions. However, the vaccination protocol did not elicit a cell-mediated
response capable of inhibiting the outgrowth of autologous Lymphoblastoid Cell Lines
(LCLs) as seen in the tamarin infected with whole EBV, even though the recombinant
vaccinia viruses used expressed the antigens commonly recognised by sero positive
humans.
Keywords
Cytotoxic T cell response , Cottontop tamarin , Epstein Barr virus , Lymphoblastoid cell lines (LCLs)
Journal title
Astroparticle Physics
Serial Year
2004
Record number
2434075
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