Author/Authors :
Movahedi, Masoud Tehran University of Medical Sciences, Tehran , Aghamohammadi, Asghar Tehran University of Medical Sciences, Tehran , Rezaei, Nima Tehran University of Medical Sciences, Tehran , Farhoudi, Abolhasan Tehran University of Medical Sciences, Tehran , Pourpak, Zahra Tehran University of Medical Sciences, Tehran , Moin, Mostafa Tehran University of Medical Sciences, Tehran , Gharagozlou, Mohammad Tehran University of Medical Sciences, Tehran , Mansouri, Davoud Maseeh Daneshvari Hospital - Beheshti University of Medical Sciences, Tehran , Arshi, Saba Rasoul Akram Hospital - Iran University of Medical Sciences, Tehran , Atarod, Lida Tehran University of Medical Sciences, Tehran , MirSaeid Ghazi, Bahram Tehran University of Medical Sciences, Tehran , Shahnavaz, Nikrad Tehran University of Medical Sciences, Tehran , Babaei Jandaghi, Ali Tehran University of Medical Sciences, Tehran , Abolmaali, Kamran Tehran University of Medical Sciences, Tehran , Mahmoudi, Maryam Tehran University of Medical Sciences, Tehran , Bazargan, Nasrin Tehran University of Medical Sciences, Tehran , Ahmadi Afshar, Akefeh Tehran University of Medical Sciences, Tehran , Nabavi, Mohammad Tehran University of Medical Sciences, Tehran
Abstract :
Chronic Granulomatous Disease (CGD) represents a group of inherited disorders of
phagocytic system, manifesting recurrent infections at different sites. The present study
was accomplished in order to determine the gastrointestinal manifestations of CGD
patients.
Fifty-seven patients (38 males and 19 females) with CGD, who had been referred to
three immunodeficiency referral centers in Iran, were studied during a 24-year period
(1980-2004).
The median age at the time of study was 14.5 years old (1-56 years). The median
onset age of symptoms was 5 months (1 month – 13.75 years), and that of diagnostic
age was 5 years (2 months- 54.1 years), with a diagnostic delay of 33 months, on
average. Seven patients were presented with acute diarrhea, 3 with oral candidiasis,
and 2 with liver abscesses as the first chief complaints. Twenty-four cases (42.1%) had
been complicated by gastrointestinal manifestations during their course of the disease.
Of those, 12 cases (21.1%) had diarrhea, 7 (12.3%) oral candidiasis, 5 (8.8%) hepatitis,
4 (7.0%) hepatic abscess, and 2 cases (3.5%) gastric outlet obstruction. Also, failure to
thrive was detected in 6 patients (10.5%). Four patients died (7%).
CGD should be excluded in any patient with gastrointestinal manifestations
especially chronic diarrhea, hepatic abscess, and gastric outlet obstruction
