Title of article
Detection of Lactoferrin in the Neutrophils and Plasma of the Patients Suffering from Hepatitis C
Author/Authors
Zarei, Nasrin Department of Immunology - Faculty of Medical Sciences - Tarbiat Modarres University, Tehran , Zavaran Hosseini, Ahmad Department of Immunology - Faculty of Medical Sciences - Tarbiat Modarres University, Tehran , Pourfathollah, Ali Akbar Department of Immunology - Faculty of Medical Sciences - Tarbiat Modarres University, Tehran
Pages
5
From page
119
To page
123
Abstract
Lactoferrin (LF) has antimicrobial properties against bacteria, fungi and several
viruses including herpes virus, HIV and hepatitis C virus.
The aim of this study was to detect LF in PMNs and plasma of the patients
suffering from hepatitis C and the healthy persons.
The sonicated solutions of PMNs of two groups were evaluated by SDS-PAGE
(10%), isoelectric focusing (30%) and dot blotting .The level of LF in plasma was
measured by ELISA.
The results confirmed the presence of LF in PMNs of the two groups. ELISA
showed that the level of LF in plasma of patients was higher than normal persons.
Based on these findings we conclude that not only the production of LF was not
reduced in the patients but also its level was significantly increased compared with the
normal persons(P<0.0001).
Keywords
Electrophoresis , Enzyme-Linked Immunosorbent Assay , Hepatitis C , Isoelectric focusing , Lactoferrin , Neutrophil , Plasma
Journal title
Astroparticle Physics
Serial Year
2005
Record number
2434331
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