Author/Authors :
Isaian, Anna Department of Allergy and Clinical Immunology of Children’s Medical Center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Moin, Mostafa Department of Allergy and Clinical Immunology of Children’s Medical Center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Pourpak, Zahra Department of Allergy and Clinical Immunology of Children’s Medical Center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Rezaei, Nima Department of Allergy and Clinical Immunology of Children’s Medical Center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Aghamohammadi, Asghar Department of Allergy and Clinical Immunology of Children’s Medical Center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Movahedi, Masoud Department of Allergy and Clinical Immunology of Children’s Medical Center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Gharagozlou, Mohammad Department of Allergy and Clinical Immunology of Children’s Medical Center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Ghaffari, Javad Department of Allergy and Clinical Immunology of Children’s Medical Center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Zandieh, Fariborz Department of Allergy and Clinical Immunology of Children’s Medical Center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Mansouri, Mahboubeh Department of Allergy and Clinical Immunology of Children’s Medical Center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Farhoudi, Abolhassan Department of Allergy and Clinical Immunology of Children’s Medical Center - Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran
Abstract :
Primary immunodeficiency disorders are a
heterogeneous group of genetic disorders, with different
modes of inheritance, consisting of more than 100
different types. We constructed the DNA banking of
primary immunodeficiency disorders for the first time in
Iran. The DNA of 31 immunodeficient patients and their
families (total of 92 samples) were collected, as the first
step for construction of DNA banking. DNA was
isolated from whole blood by salting out method. Among
our patients, Common variable immunodeficiency was
the most common disorder, followed by X-linked
agammaglobulinemia, Ataxia-telangiectasia, Chronic
granulomatous disease, Severe combined
immunodeficiency, Hyper IgM syndromes, and
Leukocyte adhesion defects. DNA banking is a useful
method for further detection of mutation in
immunodeficient patients and prenatal diagnosis for
presence or absence of the disorder in the fetus which
can be confirmed by molecular genetics testing.
