Author/Authors :
Khazaei, Hossein Ali Zahedan University of Medical Sciences, Sistan and Balochestan , Rezaei, Nima Medical Sciences/University of Tehran, Tehran , Aghamohammadi, Asghar Medical Sciences/University of Tehran, Tehran , Amirzargar, Ali Akbar Department of Immunology - School of Medicine - Medical Sciences/University of Tehran, Tehran , Mollaei Ghasemi, Khadidjeh Zahedan University of Medical Sciences, Sistan and Balochestan , MiriMoghaddam, Ibrahim Zahedan University of Medical Sciences, Sistan and Balochestan , Nikbin, Behrouz Department of Immunology - School of Medicine - Medical Sciences/University of Tehran, Tehran
Abstract :
This study was performed to determine the genetic
diversity of HLA class I and II alleles among two ethnic
groups in Southeastern Iran. HLA profiles were
determined in 71 Iranian populations (41 Zaboli and 30
Baloch). The frequencies of HLA-A02 (p=0.017), -Cw4
(p=0.003), and –DR8 (p=0.025) in the Zaboli
populations were significantly higher than that in Baloch
ethnic group. In contrast, the frequency of HLA-A23
allele was more frequent in Baloch than Zaboli
(p=0.020). This report represents an important resource
for investigators in the fields of transplantation
immunology and population genetics from widely
dispersed areas of Iran.
Keywords :
Anthropology , human leukocyte antigen , human populations , Iran
