Author/Authors :
Heydarheydari, Sahel Department of Medical Physics - Faculty of Medicine - Kermanshah University of Medical Sciences, Kermanshah , Haghparast, Abbas Department of Medical Physics - Faculty of Medicine - Kermanshah University of Medical Sciences, Kermanshah
Abstract :
Background: Despite developments in surgical treatment, radiation therapy,
and chemotherapy protocols, tumor recurrence and metastasis are still major
problems in breast cancer management. The aim of the present report was to
review and compare the performance of PET/CT with some of the conventional
imaging modalities in detection of breast cancer recurrence.
Methods: A literature search was performed in PubMed, Europe PMC and
ScienceDirect databases with no search restriction for the date of publication but
the searchwas limited to papers published inEnglish.
Results: Twenty-two studies including a total of 1378 patients with prior breast
cancer and clinical suspicion of recurrence that assessed the sensitivity, specificity,
and accuracy of PET/CT and other conventional imaging methods in followed up
by treated breast cancer and presented the results in systematic review format. The
information extracted from each article included the first author, publication year,
number of patients and their characteristics, index test(s), sensitivity, specificity,
positive predictive value (PPV), negative predictive value (NPV), and accuracy.
Conclusions: According to the literature, PET/CT seems to be a more useful
modality than current techniques to assess the patients with suspected recurrent
and metastatic breast cancer. If PET/CT is not applicable, MRI and also bone
scintigraphy could also be performed as alternatives.
Keywords :
PET/CT , recurrence , breast cancer , diagnostic value , imaging modalities
