Author/Authors :
Ravanshad, Yalda Clinical Research Development Center - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences , Azarfar, Anoush Department of Pediatrics - Faculty of Medicine, Mashhad University of Medical Sciences , Ghalegolab-Behbahan, Afshin Department of Pediatrics - Pediatrics Health Research Center - Tabriz University of Medical Sciences , Mortazavi, Fakhrosadat Department of Pediatrics - Pediatrics Health Research Center - Tabriz University of Medical Sciences , Ahmadzadeh, Sonia Department of Pediatrics Nephrology - Faculty of Medicine - Tabriz University of Medical Sciences , Ghorat, Fereshteh Traditional and Complementary Medicine Research Center - Sabzevar University of Medical Sciences , Foji, Samira Faculty Member School of Paramedical - Sabzevar University of Medical Sciences , Iziy, Elham Traditional and Complementary Medicine Research Center - Sabzevar University of Medical Sciences , Vejdan, Marjan Iranian Research Center on Healthy Aging - Sabzevar University of Medical Sciences
Abstract :
Introduction: Nocturnal enuresis is known as the most common developmental problems of childhood which has often a familial basis. It is usually benign and gradually disappears with age.
Objectives: This study was conducted on children with primary nocturnal enuresis to compare the efficacy of desmopressin and oxybutynin combination therapy with desmopressin monotherapy.
Patients and Methods: This clinical trial was conducted on 59 patients (age range; 5 to 15 years) with primary nocturnal enuresis who had referred to our center in Tabriz in 2012. The participants were divided into two groups as group 1 (30 participants) and group 2 (29 subjects). For three months, one group received desmopressin and oxybutynin and the other group received desmopressin alone. Descriptive statistics (mean ± SD and frequency) and chi-square test was conducted.
Results: In the group treated only with desmopressin, 72.4% of the participants were completely cured in 1 month and 44.8% in 3 months. In the group treated with combination of desmopressin and oxybutynin, 83.34% were cured in 1 month and 86.7% in 3 months.
Conclusion: Desmopressin and oxybutynin combination therapy is more effective than desmopressin monotherapy for treating children with enuresis.
