Author/Authors :
Mozaffarizadeh, Hengameh Department of Genetics - Isfahan University of Medical Sciences, Isfahan , Hakimian, Mohammadreza Isfahan University of Medical Sciences, Isfahan , Salehi, Mansoor Department of Genetics - Isfahan University of Medical Sciences, Isfahan , Moazam, Elham Isfahan University of Medical Sciences, Isfahan , Behjati, Mohaddeseh Iran University of Medical Sciences, Tehran , Keshvari, Mahtab Isfahan University of Medical Sciences, Isfahan , Mokarian, Faribourz Isfahan University of Medical Sciences, Isfahan
Abstract :
Background: Vitamin D serves several cancer protective roles within the
human body.Vitamin D functions through binding with the VDR encoded by VDR
gene. It has been demonstrated that polymorphism in VDR gene would influence
expression and/or function of the VDR protein. The researchers found that the
most important VDR gene polymorphisms that are associated with tumorigenesis
include Fok1 (rs2228570), Bsm1 (rs1544410), Taq1 (rs771236), and Apa1
(rs7975232) .The purpose of this study was to assess the association between Fok1,
Bsm1, and Taq1 polymorphisms and breast cancer development.
Methods: In this study, 50 patients suffering from breast cancer with less than 6
months after the diagnosis of breast cancer and 50 healthy control individuals were
included. Restriction fragment length polymorphism PCR (RFLP-PCR) was used
to determine the genotype of polymorphisms.
Results: Statistical results showed that among the studied polymorphisms, Tt
genotypes of Taq1 polymorphism have correlations with breast cancer
development (P< 0.001, OR= 5.51, 0.95 CI= 2.30-13.21).
Conclusion: The results of the present clearly demonstrated that there is a
relationship between Taq1 polymorphism in VDR gene and development of breast
cancer.
