Lipid Profile in Women with Polycystic Ovary Syndrome

Objective: Polycystic ovary syndrome (PCOS) is a disorder of hyperandrogenemia and chronic anovulation, which affects 5-10% of all women. It has been reported that women with PCOS often have serum lipid level elevation. This study compares serum lipid levels in women with and without PCOS. Materials and Methods: Lipid profile [total cholesterol (TC), apolipoprotein A-I, apolipoprotein B, high-density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG), and lipoprotein a] in this comparative cross-sectional study were compared between 33 women with and 44 women without PCOS. All biochemical tests were done using fasting blood samples which were frozen in −80 °C since the previous study. Other data were collected from Iranian twin bank. Data were analyzed with SPSS. P < 0.05 considered as significant level. Results: There was no significant difference between two groups in terms of age, age of menarche and body mass index (BMI). Serum levels of TC, apolipoprotein B, apolipoprotein A-1, HDL, LDL, TG, and lipoprotein did not show any difference between two groups. TG in PCOS women with BMI >25 was significantly higher in comparison with non-PCOS. Conclusion: The present study does not support the notion that PCOS affects serum lipid levels except in the term of TG in PCOS women with BMI > 25. It is suggested to repeat this study within PCOS patients who are insulin resistance.