The Relation of Lumbar Disc Herniation With Increased Lipid Hydroperoxide, Paraoxonase 1 and Total Oxidative Status

Objective: Lumbar disc herniation (LDH) is well known low back disorder. Beside a lot of reason, the chronic inflammation is stated to have a role in the importance of LDH. As known, there is a complex connection between inflammation and oxidative stress. The relationship between LDH and the levels of lipid hydroperoxide (LOOH), total oxidative status (TOS), paraoxonase 1 (PON1) and total antioxidative status (TAS) has not been studied until now. The purpose of this study was to evaluate the levels of oxidative markers, such as LOOH, TOS, PON1 and TAS in patients with preoperative stage of disc herniation Materials and Methods: Fifty consecutive patients (8 patients were excluded; n = 42) with LDH and 50 healthy controls were subjected in this prospective study. Serum PON1, LOOH, TAS and TOS levels were determined. Results: Serum PON-1 level was found to be significantly lower (P = 0.008), serum TAS and LOOH levels were measured as significantly higher (both P < 0.001) in the LDH group than in the control group. Positive significant correlations were detected between LOOH and TAS, TOS, and oxidative stress index (OSI); then again between OSI and low-density lipoprotein cholesterol (LDL-C). Conclusion: The inflammatory-oxidant environment decreased PON1 and increased LOOH- may be the cause or reason of disc herniation. This result suggests that LDH may be related with atherosclerosis.