Author/Authors :
Shetty, Poornima Department of Chemistry - Srinivas School of Engineering, Mukka, Mangalore , Praveen, Beekanahalli Mokshanatha Department of Chemistry - Srinivas School of Engineering, Mukka, Mangalore , Cheruku, Srinivas Department of Chemistry - Srinivas School of Engineering, Mukka, Mangalore , Raghavendra, Manjoji Department of Chemistry - Government Pre-University College, Kanasawadi, Doddaballapurataluk, Bangalore-Rural Karnataka , Manjunath, Kumsi Department of Chemistry - Nagarjuna College of Engineering & Technology, Devanahallitaluk, Bangalore
Abstract :
A series of compounds based on 6-(4-chlorophenylamino) piperidin-1-yl)pyrimidin-4-amino derivatives were synthesized and its anti-microbial potential was explored. All the synthesized compounds (5a-5m) were screened for their antibacterial and antifungal activity. Among all the compounds 5e (MIC (μg/mL)/Inhibition (mm): 6.25/19-23; cLogP: 4.66) and 5f (MIC (μg/mL)/Inhibition (mm): 6.25/22-25; cLogP: 5.21) found to have good activity in antibacterial and antifungal.
Keywords :
Pyrimidine , Piperidine , Antimicrobial activity , Anti-bacterial , Anti-fungal , Microwave
