Author/Authors :
Islam Khan, Saiful Biomedical and Toxicological Research Institute - Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhanmondi, Dhaka, Bangladesh , Islam, Dipa Institute of Food Science & Technology - Bangladesh Council of Scientific and Industrial Research (BCSIR) , Bilkis, Khadija Biomedical and Toxicological Research Institute - Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhanmondi, Dhaka, Bangladesh , Hakim, Mahmuda Biomedical and Toxicological Research Institute - Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhanmondi, Dhaka, Bangladesh , Lipy, Evena Parvin Institute of Food Science & Technology - Bangladesh Council of Scientific and Industrial Research (BCSIR) , Mohanta, Liton Chandra Institute of Food Science & Technology - Bangladesh Council of Scientific and Industrial Research (BCSIR) , Haque, Md. Zahurul Bangladesh Council of Scientific and Industrial Research (BCSIR)
Abstract :
Two substituted diamines (2-3) and their corresponding Schiff bases (4-5) have been synthesized by amination of Atorvastatin an acid with two diamines with different carbon chain followed by condensation with Isatin. Spectroscopic characterization and study of antibacterial activity as well as cytotoxicity of the synthesized compound have been made to establish the Structure Activity Relation (SAR).
Keywords :
Atorvastatin Substituted amide , Schiff base , Isatin , Antibacterial , Cytotoxicity
