Author/Authors :
Poursharifi, M. Javad Department of Chemistry - Science and Research Branch, Islamic Azad University, Tehran , Mojtahedi, Mohammad M. Department of Organic Chemistry and Natural Products - Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran , Abaee, M. Saeed Department of Organic Chemistry and Natural Products - Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran , Hashemi, Mohammad M. Department of Organic Chemistry - Faculty of Chemistry - Sharif University of Technology Tehran
Abstract :
A facile synthesis of heterocyclic ketone 2 is reported in this work. The procedure takes place in one pot and gives a satisfactory yield. In comparison with other major reported procedures, the present method uses much easier conditions and inexpensive reagents. Ketone 2 is subsequently employed in aldol condensation reactions to give the respective bisarylmethylidene products under sonochemical conditions. Reactions proceed rapidly and products are obtained in relatively high yields. The efficiency of both reactions, use of inexpensive and commercially available reagents, and safe and mild conditions used for the reactions are amongthe advantages of this work.
Keywords :
Ninhydrin , Primary amine , Arylisothiocyanates , Dialkyl acetylenedicarboxylates , Multi component reaction
