Streptomycin loaded TiO2 nanoparticles: preparation, characterization and antibacterial applications

We report a facile synthesis of Titanium dioxide (TiO2) nanoparticles by sol gel technique assisted by biogenic route using the rind of Aloevera and demonstrate the antibacterial assessment against human pathogens causing urinary tract infection. The synthesized nanoparticles were characterized by powder XRD analysis, FT-IR analysis and scanning electron microscopic analysis. The XRD spectrum confirmed that the synthesized TiO2 nanoparticles exhibit anatase phase. Average grain size was calculated using Debye–Scherrer formula and it was found to decrease from 13 to 8 nm with increasing template concentration. FTIR spectrum showed characteristic bands at 1626, 1056 and 1074 cm-1 revealing C–N stretching of amino groups present in the protein cages of Aloevera which assist in the formation of TiO2 nanoparticles. Morphological characterization analyzed by SEM showed nanocoral network and all the networks displayed excellent invitro bioactivity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Salmonella typhi and Proteus mirabilis. Drug delivery was assessed by the release of anti-inflammatory streptomycin which is evidenced by the release profile suggesting that it has the potential to provide better deliveries.