Author/Authors :
Y assin, MM Department of Physiology - Faculty of Medicine - The Islamic University of Gaza - Gaza Strip, Palestine , Altibi, HI Ministry of Health, -Al Shifa Hospital - Clinical Chemistry Laboratory, Gaza – Palestine , El Shanti, AF Department of Medical Sciences - College of Science and Technology - Khan Yunis - Gaza Strip, Palestine
Abstract :
characterized by severalmetabolic disorders. Its prevalence
rate in Gaza Strip is alarming.
OBJECTIVE: To describe the clinical and biochemical features
of patients with Type 2 diabetes in Gaza Governorate.
METHODS: Data were obtained through a questionnaire
interview, patients’ records and of 99 type 2 diabetes patients
and 95 healthy individuals.
RESULTS: Family history and obesity were risk factors for
diabetes. The mean age at diagnosis was 41.7±8.1 years. Fifty
five (55.6%) patients had diabetes since d”5 years. Distribution
of diagnosed diabetic complications was low. Micro- and
macroalbuminuria in controls and patients (8.4 v 22.2% and
9.5 v 22.2%, respectively) were associated with diabetes
(÷2=7.06, P=0.007 and ÷2=5.87, P=0.015, respectively).
HbA1c% was significantly higher in diabetics (6.93+1.22 v
5.36+0.57, p<0.001). Serum urea and creatinine were
significantly decreased in diabetics than controls
(mean=23.5±6.9 v 27.2±7.4 and 0.49±0.15 v 0.58±0.14, %
differences=13.6 and 15.5, respectively, p=0.000). Alkaline
phosphatase (ALP) was increased in diabetics (136.9±38.7 v
117.4±23.5, % difference=16.6, p=0.001). Cholesterol,
triglycerides and low density lipoprotein cholesterol (LDLC)
were significantly higher in diabetics (207.6±36.5,
184.1±104.5 and 124.6±32.9) than controls (181.2±39.1,
139.8±76.1 and 102.2±37.4) with % differences of 14.6, 31.7
and 21.9%, respectively, p<0.001. In contrast, high density
lipoprotein cholesterol (HDLC) was significantly lower in
diabetics (42.6±7.8 v 48.2±5.7, % difference=11.6 and
p<0.001).
CONCLUSIONS: Diabetes was associated with family history,
obesity and micro- or macroalbuminuria. HbA1c%, ALP,
cholesterol, triglycerides and LDLC were higher in diabetics
than controls. In contrast, urea, creatinine and HDLC were
lower in diabetics.
Keywords :
complications , Family history , albuminuria , Type 2 Diabetes , Lipids , Gaza Strip , Clinical and Biochemical Features , Palestine