Title of article :
A convenient method for 14C-labeling of N-(7-chloro-1- methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[ e][1,4]diazepin-3-yl)thiophene-2-carboxamide as CCK-A antagonist
Author/Authors :
Saemian, Nader Nuclear science Research School - Nuclear Science & Technology Research Institute , Shirvani, Gholamhossein Nuclear science Research School - Nuclear Science & Technology Research Institute , Javaheri, Mohsen Nuclear science Research School - Nuclear Science & Technology Research Institute
Abstract :
N-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)thiophene-2 carboxamide-
[14C-carboxy] was prepared as part of a 6-step sequence from thiophene-2-carbonitrile -[cyano-14C] as a key
synthetic intermediate which has been synthesized from 2-iodothiophene and zinc [14C]-cyanide in the
presence of tetrakis (triphenylphosphine) palladium.
Keywords :
thiophene-2-carbonitrile , Cholecystokinin antagonist , Carbon-14 , benzodiazepin
Journal title :
Astroparticle Physics
