Title of article
Distribution and Diversity of hmw1A Among Invasive Nontypeable Haemophilus influenzae Isolates in Iran
Author/Authors
Shahini Shams Abadi, Milad Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran, Tehran , Siadat, davar Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran, Tehran , vaziri, farzam Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran, Tehran , davari, farzam Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran, Tehran , davari, mehdi Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran, Tehran , fateh, abolfazl Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran, Tehran , Pourazar, shahin Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran, Tehran , Abdolrahimi, farid Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran, Tehran , Ghazanfari, morteza Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran, Tehran
Pages
4
From page
99
To page
102
Abstract
Background:
The pathogenesis of nontypeable Haemophilus influenzae (NTHi) begins with adhesion to the rhinopharyngeal mucosa. Almost 38–80% of NTHi clinical isolates produce proteins that belong to the High Molecular Weight (HMW) family of adhesins, which are believed to facilitate colonization.
Methods:
In the present study, the prevalence of hmwA, which encodes the HMW adhesin, was determined for a collection of 32 NTHi isolates. Restriction Fragment Length Polymorphism (RFLP) was performed to advance our understanding of hmwA binding sequence diversity.
Results:
The results demonstrated that hmwA was detected in 61% of NTHi isolates. According to RFLP, isolates were divided into three groups.
Conclusion:
Based on these observations, it is hypothesized that some strains of nontypeable Haemophilus influenzae infect some specific areas more than other parts.
Keywords
Adhesins , Haemophilus influenza , HMW1 protein
Journal title
Astroparticle Physics
Serial Year
2016
Record number
2440386
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