Author/Authors :
Emami, Sahar Department of Veterinary - Shushtar Branch - Islamic Azad University, Shushtar, Khuzestan , Olfati, Ali Department of Animal Sciences - University of Tabriz, Tabriz
Abstract :
Background: Microalgae are known to have beneficial effects on health. On the other hand, studies have
reported negative effects of diabetes on hematological parameters. Effects of Spirulina platensis (SP) and
Chlorella vulgaris (CV) microalgae, singly and combined, on hematological parameters in diabetic rats are not
still studied. Thus, the present study was conducted to investigate the effects of SP and CV microalgae on
hematological parameters in Streptozotocin-induced diabetic rats.
Materials and Methods: This interventional study was conducted in Tabriz University of Medical Science
between October and November 2016. Diabetes was induced by intraperitoneal administration of
Streptozotocin. Thirty-six Wistar rats were treated with CV, SP and their combination for 28 days. Two groups
including diabetic control and healthy control were also considered. Blood samples were collected to investigate
the levels of hemoglobin (Hb), packed cell volume (PCV), red blood cell count (RBC), white blood cell count
(WBC), platelet count, lymphocytes, neutrophils, plasma iron and selenium and glutathione peroxidase (GPx)
activity in erythrocytes at 14 and 28 days of trial.
Results: Results showed that dietary supplementing of CV and SP microalgae, alone and combination form,
could increase the reduced levels of RBC, WBC, platelet, PCV, GPx activity, and selenium in diabetic rats on
28 days (P<0.05).
Conclusion: It can be concluded that dietary supplementing of CV and SP microalgae, especially combined
form, may partly improve deleterious effects of diabetes on hematological parameters.
