Author/Authors :
Sheikhpour, Elnaz Hematology and Oncology Research Center - Shahid Sadoughi University of Medical Sciences, Yazd , Sadri, Zahra Hematology and Oncology Research Center - Shahid Sadoughi University of Medical Sciences, Yazd , Ghanizadeh, Fatemeh Hematology and Oncology Research Center - Shahid Sadoughi University of Medical Sciences, Yazd , Zare-Zardini, Hadi Hematology and Oncology Research Center - Shahid Sadoughi University of Medical Sciences, Yazd , Hashemi, Azam Hematology and Oncology Research Center - Shahid Sadoughi University of Medical Sciences, Yazd , Heydari, Safiyehsadat Department of Research and Technology - Shahid Sadoughi University of Medical Sciences, Yazd , Atefi, Aref Department of Research and Technology - Shahid Sadoughi University of Medical Sciences, Yazd , Fallah, Tahereh Shahid Sadoughi Hospital - Shahid Sadoughi University of Medical Sciences, Yazd , Ghiaspour, Esmat Shahid Sadoughi Hospital - Shahid Sadoughi University of Medical Sciences, Yazd
Abstract :
Vitamin D deficiency is known as the most common nutritional deficiency. It is created during infancy due to
different factors, including decreased dietary intake, decreased dermal synthesis, malabsorption, enzymeinducing
medications, and exclusive breastfeeding. Vitamin D deficiency is associated with poor bone health
such as rickets and osteomalacia in children. Despite vitamin D plays an important role in bone health, its role in
pediatric cancer is not detected and remained unknown; therefore, the aim of this study was to evaluate the role
of vitamin D deficiency and its relation with cancer in children. Vitamin D in cancer children has been
considered as a contributory factor for skeletal pathologies. Children with cancer may be at increased risk of
vitamin D deficiency due to side effects which are induced by the disease and multiple treatments, given that
chemotherapy and clinical radiation play a main role in decreased bone mineral density. Therefore, possible role
of vitamin D deficiency in cancer pathogenesis and progression is well defined. It seems that these patients
should be taken sufficient amount of calcium and vitamin D during chemotherapy and afterward.
