Author/Authors :
Ayatollahi, Hossein Anatomo Clinical Pathologist - Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences, Mashhad , Asgharzadeh, Ali Mashhad University of Medical Sciences, Mashhad , Keramati, Mohammad Reza Anatomo Clinical Pathologist - Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences, Mashhad , Sadeghian, Mohammad-Hadi Anatomo Clinical Pathologist - Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences, Mashhad , Rafiee, Mohammad Department of Hematology and Blood Banking - School of Allied Medical Sciences - Shahid Beheshti University of Medical Sciences, Tehran , Balali-Mood, Mahdi Medical Toxicology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad , Amiri, Vahid Anatomo Clinical Pathologist - Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences, Mashhad
Abstract :
Background: Sulfur mustard (SM) is a chemical blistering warfare that affects different organs
especially hematopoietic system. Prevalence of acute myeloblastic and lymphoblastic leukemia is
increased by sulfur mustard exposure. FLT3-ITD mutation can be effective on leukemogenesis.
Therefore, the aim of this study was to verify the frequency of FLT3-ITD mutation in the patients
who exposed to SM.
Methods: This study was implemented on 42 people poisoned by SM during Iraq-Iran war about
three decades ago and is now resident in Mashhad, Iran. The control group included 30 healthy
males that are relatives of the patients with first-degree. After DNA extraction, PCR was performed
for FLT3-ITD analysis.
Results: By analysis of PCR products, no FLT3-ITD mutation was detected in the patient or
control groups. There was no significant difference in hematological factors between the two
groups.
Conclusion: Other mechanisms can lead to leukemia in SM exposed persons. Elapsed time after
exposure to sulfur mustard can be effective on leukemogenesis, then future more study may be
beneficial for early diagnosis of leukemia in SM exposed veterans.
Keywords :
FLT3 , Iran , Leukemia , Mutation , Sulfur Mustard
