Title of article :
Interferon-Beta-1b Induced Autoimmune Hemolytic Anemia in a Patient with MS: A Case Report
Author/Authors :
Saeedi, M Department of Neurology - Ghaem Hospital - Mashhad University of Medical Sciences, Mashhad , Forughipour, M Department of Neurology - Ghaem Hospital - Mashhad University of Medical Sciences, Mashhad , Sasannezhad, P Department of Neurology - Ghaem Hospital - Mashhad University of Medical Sciences, Mashhad , Shoeibi, A Department of Neurology - Ghaem Hospital - Mashhad University of Medical Sciences, Mashhad
Abstract :
A 26-year-old lady with the diagnosis of multiple sclerosis who had received interferon beta1-b for eleven months
was visited in MS clinic of our hospital because of icter and fatigue. Laboratory tests showed anemia, indirect
hyperbillirubinemia, increased LDH, positive direct and indirect coomb’s tests, and increased reticulocyte count
and percentage. Other causes of autoimmune hemolytic anemia (AHA) and pre-existing AHA in the patient were
ruled out. After INF discontinuation, symptoms disappeared, hemoglobin increased, and indirect coomb’s test
became negative. We concluded that autoimmune hemolytic anemia should be considered in all MS patients
who receive interferon beta1-b and present with symptoms and signs of anemia.
Keywords :
Multiple sclerosis , Interferon beta , Haemolytic anemia
Journal title :
Astroparticle Physics
