Author/Authors :
Fatemi, Iman Department of Physiology and Pharmacology - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Bazmandegan, Gholamreza Department of Physiology and Pharmacology - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Kaeidi, Ayat Department of Physiology and Pharmacology - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Shamsizadeh, Ali Department of Physiology and Pharmacology - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Hassanipour, Mahsa Department of Physiology and Pharmacology - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Amirteimoury, Morteza Clinical Research Development Center - Ali Ibn Abitaleb Hospital - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Khademalhosseini, Morteza Department of Pathology - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Nematollahi, Mohammad Hadi Department of Clinical Biochemistry - Kerman University of Medical Sciences - Kerman, Iran
Abstract :
Cisplatin (Cis) is an anticancer compound, which is used for the treatment of various
cancers. Sumatriptan (Suma) is a selective agonist of 5-hydroxytryptamine 1B/1D (5HT1B/1D)
receptor, which is prescribed for the management of migraine. It is well-established that Suma has
anti-inflammatory and antioxidant properties. We have explored the protective effects of Suma in the
mitigation of Cis-induced nephrotoxicity.
Materials and Methods: The mice received a single IP injection of Cis (20 mg/kg) on the first day of
the experiment. Suma treatment (0.1 and 0.3 mg/kg/day, IP) was started on day 1 and continued for 3
consecutive days.
Results: Creatinine (Cr), blood urea nitrogen (BUN) and malondialdehyde (MDA) levels were elevated
and glutathione peroxidase (GPx) as well as superoxide dismutase (SOD) activities were decreased
in Cis-treated mice. Suma (more potently 0.3 mg/kg) reduced Cr, BUN and MDA levels and increased
SOD and GPx levels. Suma also reduced the acute renal injury (tubular degeneration, tubular cells
vacuolation, tubular necrosis and cast), which corresponded to kidney damage in Cis-treated mice.
Conclusion: These findings demonstrate that Suma mitigates Cis-induced renal injury by inhibition of
oxidative stress and enhancing the antioxidant enzymes activities.
Keywords :
Cisplatin , Mice , Nephrotoxicity , Oxidative stress , Sumatriptan
