Title of article :
Expression of Prostate-Specific Membrane Antigen (PSMA) in Brain Glioma and its Correlation with Tumor Grade
Author/Authors :
Saffar, Hiva Shariati Hospital - Tehran University of Medical Sciences , Noohi, Maryam Shariati Hospital - Tehran University of Medical Sciences , Tavangar, Mohammad Shariati Hospital - Tehran University of Medical Sciences , Saffar, Hana Imam Hospital Complex, Tehran University of Medical Sciences , Azimi, Sima Shariati Hospital - Tehran University of Medical Sciences
Abstract :
Background & Objective Angiogenesis is an essential component of tumor
growth. Expression of PSMA on the neo-vasculature of many solid tumors, including
glioblastoma multi-form, has been determined. The pattern of expression suggests
that PSMA may play a functional role in angiogenesis.
Methods: expression of PSMA in different grades of brain glioma was evaluated
by the immunohistochemistry method to determine the probable usefulness of antiPSMA antibody as complementary target therapy in different grades of glioma.
Results: Overall, 72 cases of low (grade I and II) and high (grade III and IV)
grade gliomas were evaluated for expression of PSMA. Positive PSMA staining was
observed in 12 (33.3%) of high grade and 3 (8.3%) of low grade gliomas. Although,
high grade tumors more commonly had positive result for PSMA (P value=0.009),
the intensity of staining was significantly stronger in low-grade tumors (P
value=0.009).
Conclusion: Expression of PSMA in different grades of glioma might provide a
basis for further investigations focusing on selective target therapy in combination
with the current standard care in all glioma grades, to improve treatment efficacy
Keywords :
Prostate-Specific Membrane , Antigen , Glioma , Grade , Tumor Angiogenesis
Journal title :
Astroparticle Physics
