Title of article :
COMPARING SERUM LEPTIN and ADIPONECTIN LEVELS IN CONTROLLED and NON-CONTROLLED TYPE 2 DIABETES
Author/Authors :
Farahnak, Zahra Department of Nutrition and Biochemistry - School of Public Health and Institute of Public Health Research - Tehran University of Medical Science , DJalali, Mahmoud Department of Nutrition and Biochemistry - School of Public Health and Institute of Public Health Research - Tehran University of Medical Science , Hosseinzadeh, Mohammad Javad Department of Nutrition and Biochemistry -School of Public Health and Institute of Public Health Research - Tehran University of Medical Science , Eshragheian, Mohammad Reza Department of Nutrition and Biochemistry - School of Public Health and Institute of Public Health Research - Tehran University of Medical Science
Abstract :
INTRODUCTION: It has been demonstrated in recent studies that abnormal levels of adipocytokines
may contribute to insulin resistance and type 2 diabetes. The aim of the present study
was to compare serum leptin and adiponectin levels in controlled and non-controlled type 2 diabetes.
METHODS: 117 patients with controlled and non-controlled type 2 diabetes were studied. Patient,
were divided into two groups based on their serum HbA1c level; there were 62 patients in
the controlled group (6 %< HbA1c≤ 8%) and 55 patients in uncontrolled group (HbA1c>8%).
Parameters like age, sex, duration of diabetes and biochemical indicators such as fasting blood
sugar, HbA1c, insulin resistance, leptin and adiponectin were determined.
RESULTS: Higher leptin and lower adiponectin levels were observed in non-controlled type 2
diabetes. The levels of fasting blood sugar and insulin resistance were significantly higher in the
non-controlled group (P<0.05).
CONCLUSION: Leptin and adiponectin may play an important role in the regulation of insulin
sensitivity and control of type 2 diabetes.
Keywords :
Type 2 Diabetes , Insulin resistance , Leptin , Adiponectin
Journal title :
Astroparticle Physics
