Author/Authors :
Mortzzavimoghaddam, Gholamreza Department of Internal Medicine - Vali-e-asr Hospital - Birjand University of Medical Sciences , Zarban, Asghar Department of Biochemistry - Faculty of Medicine - Birjand University of Medical Sciences , Rezvani, Mohammadreza Department of Internal Medicine - Vali-e-asr Hospital - Birjand University of Medical Sciences
Abstract :
INTRODUCTION: Dyslipidemia and oxidative stress are thought to be important mechanisms in
pathogenesis of disease in hemodialysis patients. This study was designed to investigate the efficacy
of oral vitamin E supplementation on lipid profile and oxidative stress in hemodialysis patients.
METHODS: The study group consisted of 26 uremic patients (10 women and 16 men), 16-68
years of age undergoing maintenance hemodialysis three times a week (12 hours/week), lasting
a range of 6-108 months, at Vali-e-Asre Hospital in Birjand (Iran). Total Antioxidant Capacity
(TAC), lipid peroxidation, cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein
levels were determined before and after oral vitamin E supplementation, 400 mg/d
for 90 days.
RESULTS: Vitamin E supplementation caused a significant decrease in ThioBarbituric Acid
Reactive Substances (TBARS) level as a marker for lipid peroxidation (2.97±0.52 vs. 2.55±0.44,
P<0.001) and a significant increase in plasma TAC (1252±348 vs. 1398±372, P<0.01). Although
there was a decrease in the level of lipid profile, there were no statistically significant differences
in the means of cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein
before and after vitamin E supplementation among patients.
CONCLUSION: Our results indicated that oral vitamin E supplementation might be able to modify
oxidative stress by an increase in TAC, and a decrease in lipid peroxidation; that could be considered
as a preventive strategy in hemodialysis patients.
Keywords :
Antioxidant capacity , lipid peroxidation , lipid profile , vitamin E , hemodialysis
