Effect of Systemic Administration of Curcumin on Ischemia-Reperfusion Injury in Ovaries: An Animal Model Study

Objective- Ovarian torsion must be diagnosed and treated as much early as possible. The aim of the present study was to investigate effects of intraperitoneal administration of curcumin on ischemia-reperfusion injury in ovaries. Design- Experimental Study. Animals- Twenty-four healthy female Wistar rats. Procedures- Twenty-four healthy female Wistar rats weighing approximately 260g were randomized into four experimental groups (n = 6): Group Sham: The rats underwent only laparotomy. Group I: A 3- hour ischemia only. Group I/R: A 3-hour ischemia and a 3-hour reperfusion. Group I/R/C: A 3-hour ischemia, a 3-hour reperfusion and 1 mg/kg intraperitoneal administration of curcumin 2.5 hours after induction of ischemia. Results- Curcumin treated animals showed significantly ameliorated development of ischemia and reperfusion tissue injury compared to those of other groups (p<0.05). The significant higher values of SOD, GPO and GST were observed in I/R/C animals compared to those of other groups (p<0.05). The damage indicators (MDA) was significantly lower in I/R/C animal compared to those of other groups (p<0.05). Conclusion and clinical relevance- Intraperitoneal administration of curcumin could be helpful in minimizing ischemia-reperfusion injury in ovarian tissue exposed to ischemia