Title of article :
RELATIONSHIPS OF SERUM LEPTIN CONCENTRATION WITH INSULIN, GLUCOSE, HbA1c LEVELS and INSULIN RESISTANCE IN OVERWEIGHT POST-MENOPAUSAL DIABETIC WOMEN
Author/Authors :
Taghdir, Maryam Department of Nutrition and Biochemistry - School of Health - Tehran University of Medical Sciences, Tehran , Djazayeri, Abolghasem Department of Nutrition and Biochemistry - School of Health - Tehran University of Medical Sciences, Tehran , Djalali, Mahmoud Department of Nutrition and Biochemistry - School of Health - Tehran University of Medical Sciences, Tehran , Eshraghian, Mohammadreza Department of Biostatistics - School of Health - Tehran University of Medical Sciences, Tehran , Rajab, Asadollah , Sadrzade Yegane, Haleh Department of Nutrition and Biochemistry - School of Health - Tehran University of Medical Sciences, Tehran , Ashourpour, Mahkameh Department of Nutrition and Biochemistry - School of Health - Tehran University of Medical Sciences, Tehran , Sepandi, Mojtaba Department of Epidemiology and Biostatistics - School of Health - Jondishapour University of Medical Sciences, Ahwaz
Abstract :
BACKGROUND: Leptin, the product of the ob gene, could have a role in the pathogenesis of obesity
and non-insulin dependent diabetes mellitus (NIDDM). The aim of this study was to investigate
relationships between serum leptin concentration and insulin, glucose, HbA1c levels and
insulin resistance in diabetic women.
METHODS: We studied 45 diabetic women and 45 healthy women (controls) who aged 45-60
years and had BMI of 25-30 kg/m2. Serum leptin, insulin, HbA1c, fasting blood sugar and insulin
resistance were determined in the two groups.
RESULTS: There was a significant positive correlation between leptin and insulin (r = 0.295, P
= 0.049) and insulin resistance (r = 0.329, P = 0.027) in controls but non-significant correlation
between leptin and HbA1c and fasting blood sugar were observed in the two groups.
CONCLUSION: This study did not document any significant relationship between serum leptin
and insulin, glucose, HbA1c and insulin resistance in diabetic women.
