Author/Authors :
Tripathi, Santanu Kumar Department of Clinical and Experimental Pharmacology - Calcutta School of Tropical Medicine, Kolkata, India , Paik, Sabyasachi Department of Clinical and Experimental Pharmacology - Calcutta School of Tropical Medicine, Kolkata, India , Maitra, Aditi Department of Clinical and Experimental Pharmacology - Calcutta School of Tropical Medicine, Kolkata, India , Bhattacharyya, Shashwat Department of Ophthalmology - Calcutta National Medical College, Kolkata, India , Pathak, Prerna Department of Dermatology and Venereology - Calcutta School of Tropical Medicine, Kolkata, India
Abstract :
Fixed drug eruption (FDE) is a unique type of cutaneous drug
reaction that typically recurs in the identical locations on
re-exposure to the attributed drug. FDE is characterized by the
appearance of a single or multiple sharply demarcated violaceous
erythematous plaques which heal with residual hyperpigmentation.
A 27-year-old woman presented with multiple dark patches over
her eyelids, mouth, lips, and shoulders of 1 week’s duration.
These lesions followed multiple erythematous plaques over the
same areas which appeared within 4 hours of the intake of an
ondansetron tablet, 12 days previously. The case was diagnosed
as post-inflammatory hyperpigmentation following ondansetroninduced
FDE. There was an identical episode 1 year earlier due
to the intake of the same drug. The causality assessment pointed
toward a probable/likely association as per the Naranjo algorithm
and the WHO–UMC scale. There have been only a few cases of
FDE due to ondansetron in the reported literature.
Keywords :
Ondansetron , Hyperpigmentation , Fixed drug eruption , 5HT3 receptor antagonists
