Author/Authors :
Morowati, Saeid Research Center for Human Genetics - Baqiyatallah University of Medical Sciences, Tehran , Yasini, Mobin Research Center of Molecular Biology - Baqiyatallah University of Medical Sciences, Tehran , Ranjbar, Reza Research Center of Molecular Biology - Baqiyatallah University of Medical Sciences, Tehran , Peivandi, Ali Asghar Faculty of Medicine - Shahid Beheshti University of Medical Sciences, Tehran , Ghadami, Mohsen Medical Genetics Department - Faculty of Medicine - Tehran University of Medical Sciences
Abstract :
Ankyloglossia (tongue-tie) is a congenital anomaly with a prevalence of 4–5% and characterized
by an abnormally short lingual frenulum. For unknown reasons the abnormality seems to be more common in
males. The pathogenesis of ankyloglossia is not known. The authors report a family with isolated
ankyloglossia inherited as an autosomal dominant or recessive trait. The identification of the defective
gene(s) in these patients might reveal novel information on the pathogenesis of this disorder.
