Title of article
Calcium Based Non-viral Gene Delivery: An Overview of Methodology and Applications
Author/Authors
Khosravi-Darani, Kianoush National Nutrition and Food Technology Research Institute - Shahid Beheshti Medical University, Tehran , Mozafari, Mohamaad Reza Department of Biochemistry and Molecular Biology - Monash University - Clayton - Victoria - 3800, Australia , Rashidi, Ladan Department of Food & Agriculture Research - Institute of Standard and Industrial Research of Iran, Karaj , Mohammadi, Mehrdad National Nutrition and Food Technology Research Institute - Shahid Beheshti Medical University, Tehran
Pages
9
From page
133
To page
141
Abstract
Application of therapeutic gene transfer in the treatment of genetic diseases is a notable progress
but there are some disadvantages and limitations in it. The process of overcoming these barriers is a drastic
change in gene delivery. Recently, calcium phosphate nanoparticles alone, or in combination with viral and
nonviral vectors, were found to have a positive effect on gene transfer especially when incorporated in the
colloidal particulate systems. This review elaborates on various successful methods of using calcium
phosphate nanoparticles in gene delivery, which are considered an advancing approach to gene delivery.
Keywords
Calcium phosphate , nanoparticles , gene transfer techniques , transfection
Journal title
Astroparticle Physics
Serial Year
2010
Record number
2445624
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