Author/Authors :
Khosravi-Darani, Kianoush National Nutrition and Food Technology Research Institute - Shahid Beheshti Medical University, Tehran , Mozafari, Mohamaad Reza Department of Biochemistry and Molecular Biology - Monash University - Clayton - Victoria - 3800, Australia , Rashidi, Ladan Department of Food & Agriculture Research - Institute of Standard and Industrial Research of Iran, Karaj , Mohammadi, Mehrdad National Nutrition and Food Technology Research Institute - Shahid Beheshti Medical University, Tehran
Abstract :
Application of therapeutic gene transfer in the treatment of genetic diseases is a notable progress
but there are some disadvantages and limitations in it. The process of overcoming these barriers is a drastic
change in gene delivery. Recently, calcium phosphate nanoparticles alone, or in combination with viral and
nonviral vectors, were found to have a positive effect on gene transfer especially when incorporated in the
colloidal particulate systems. This review elaborates on various successful methods of using calcium
phosphate nanoparticles in gene delivery, which are considered an advancing approach to gene delivery.
Keywords :
Calcium phosphate , nanoparticles , gene transfer techniques , transfection
