Author/Authors :
Eskandari-Nasab, Ebrahim Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences , Moghadampour, Mehdi Department of Microbiology - School of Medicine, Isfahan University of Medical Sciences , Tahmasebi, Arezoo Department of Statistical and Actuarial Sciences - University of Western Ontario (UWO), London, ON, Canada
Abstract :
Background: CTX-M-type extended-spectrum β-lactamases
(ESBLs) are the most prevalent ESBLs in bacterial members
of Enterobacteriaceae family including Klebsiella pneumoniae.
The global spread of CTX-M-producing K. pneumoniae is a
major concern in most countries including Iran. The aim of this
meta-analysis was to determine the relative frequency (RF) of
blaCTX-M gene among ESBLs-producing K. pneumoniae clinical
isolates in Iran and to report an overall prevalence.
Methods: A comprehensive literature search of studies published up
to July 2016 was carried out. The keywords “Enterobacteriaceae”,
“Klebsiella pneumoniae”, “ESBLs”, “CTX-M” and “Iran” were
searched in PubMed, Scopus, EBSCO, Google Scholar, Scirus, SID
and IranMedex in both English and Persian. Selected articles were
published between July 2010 and July 2016 and all of them were in
English. STATA SE version 11.0 was used for statistical analysis.
Results: Twenty-four articles/abstracts were included in this
analysis. Selected studies were performed in Ahvaz, Arak, Ilam,
Kashan, Kerman, Mashhad, Shiraz, Tabriz, Tehran, Zabol, and
Zahedan. Our pooled evidence showed that the RF of blaCTX-M
gene among ESBLs-producing K. pneumoniae clinical isolates
varied from 7.7% in Tabriz to 100% in Mashhad, Tehran, and
Zahedan, with an overall RF of 56.7%.
Conclusion: Our meta-analysis revealed that the RF of
CTX-M-type ESBLs-producing K. pneumoniae is diverse in
different regions of Iran, and the central and eastern regions had
higher prevalence rates compared to western regions.
Keywords :
Extended-spectrum beta-lactamase , blaCTX-M , Klebsiella pneumoniae , CTX-M
