Author/Authors :
Davoodabadi, Zeynab Cardiac Rehabilitation Research Center - Cardiovascular Research Institute - Isfahan University of Medical Sciences, Isfahan, Iran , Soleimani, Azam Heart Failure Research Center - Cardiovascular Research Institute - Isfahan University of Medical Sciences, Isfahan, Iran , Pourmoghaddas, Ali Interventional Cardiology Research Center - Cardiovascular Research Institute - Isfahan University of Medical Sciences, Isfahan, Iran , Hosseini, Mohsen Department of Biostatistics and Epidemiology - School of Public Health - Isfahan University of Medical Sciences, Isfahan, Iran , Jafari-Koshki, Tohid Department of Statistics and Epidemiology - School of Health - Tabriz University of Medical Sciences, Tabriz, Iran , Rahimi, Mojtaba 6- Department of Anesthesiology - School of Medicine - Isfahan University of Medical Sciences, Isfahan, Iran , Shishehforoush, Mansour Isfahan Disaster Management Office - Isfahan Governor’s Office, Isfahan, Iran , Lahijanzadeh, Ahmadreza Khouzestan Department of Environment, Ahvaz, Iran , Sadeghian, Babak Central Laboratory and Air Pollution Monitoring - Isfahan Province Environmental Monitoring Center - Isfahan Department of Environment, Isfahan, Iran , Moazam, Elham Cancer Prevention Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Mohebi, Mohammad Bagher Information Technology Offic - Isfahan University of Medical Sciences, Isfahan, Iran , Ezatian, Victoria Isfahan Meteorological Office, Isfahan, Iran , Rabiei, Katayoun Isfahan Cardiovascular Research Center - Cardiovascular Research Institute - Isfahan University of Medical Sciences, Isfahan, Iran , Nizal Sarrafzadegan Isfahan Cardiovascular Research Center - Cardiovascular Research Institute - Isfahan University of Medical Sciences, Isfahan, Iran
Abstract :
BACKGROUND: Air pollution is associated with increased risk of cardiovascular disease (CVD).
This study aims to evaluate the correlation between air pollutants and hospitalization due to
myocardial infarction (MI) as part of "correlation of air pollution with hospitalization and
mortality of CVDs and respiratory diseases (CAPACITY) study".
METHODS: This case-crossover study analyzed the data of 319 patients who were admitted with
diagnosis of ST-elevation MI (STEMI) or non-ST-elevation MI (NSTEMI) in three main
hospitals of Isfahan, Iran. The data of airborne pollutants including particulate matter < 10 μm
(PM10), particulate matter < 2.5 μm (PM2.5), nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon
monoxide (CO), and ozone (O3) as well as climatic indices (temperature, wind speed, and
humidity) at 24 hours, 48 hours, and one week before admission were extracted from
CAPACITY study. The conditional logistic regression method was used to evaluate the
correlation between air pollutants and MI hospitalization.
RESULTS: 319 patients with mean age of 63.15 ± 28.14 years, including 238 men (74.6%), and 207
patients with STEMI (64.8%) were recruited. The risk of hospitalization significantly increased in
patients with STEMI and 10-unit increment in PM2.5 at 48 hours before admission [odds ratio
(OR) = 3.70, 95% confidence interval (CI): 1.69-7.69]. Although, majority of air pollutants had positive
association with hospitalization in patients with NSTEMI, they were not statistically significant.
CONCLUSION: This study showed significant association between elevated PM2.5 at 48 hours before
admission and hospitalization of patients with STEMI. This finding can warn policymakers to design
better care services for patients at risk of acute MI during the times of increased air pollution.
