Title of article :
Effects of hyperbaric oxygenation on survival time of aluminum phosphide intoxicated rats
Author/Authors :
Saidi, Hossein Assistant Professor - Department of Emergency - Rasoul-e-Akram Hospital, Tehran University of Medical Sciences , Shokraneh, Farhad Research Instructor - Research Center for Pharmaceutical Nanotechnology and Clinical Librarian, Iranian Center for Evidence Based Medicine, Tabriz University of Medical Sciences , Ghafouri, Hamed-Basir Assistant Professor - Department of Emergency - Sina Hospital, Tehran University of Medical Sciences , Shojaie, Shayan Resident - Department of Emergency - Rasoul-e-Akram Hospital, Tehran University of Medical Sciences
Abstract :
BACKGROUND: Aluminium phosphide (AlP) is used as a fumigant. It produces phosphine gas which is a mitochondrial
poison. Although this poisoning has been repeatedly reported in literature with a high mortality rate, there is no known
antidote for AlP intoxication. In the present study, we studied the effects of hyperbaric oxygenation (HBO) on the survival
time of AlP intoxicated rats.
METHODS: Intoxicated rats with AlP (11.5 mg/kg, oral gavage) were placed in hyperbaric oxygenation with different
concentrations of compressed air and oxygen.
RESULTS: All the animals exposed to AlP died within 5 days. The mean survival times of rats exposed to AlP without
any intervention, treated with hyperbaric condition by compressed air, and treated with hyperbaric condition by pure O2
were 91 ± 1, 262 ± 8, and 276 ± 6 minutes, respectively. In analysis of survival times, there was a significant difference
between Group 2 which received AlP and the groups which underwent intervention (Groups 2 and 3, p < 0.001; Groups
2 and 4, p < 0.001).
Keywords :
Intoxication , Aluminium Phosphide , Hyperbaric Oxygen Therapy , Oxygen , Compressed Air
Journal title :
Astroparticle Physics
