Title of article
Intellectual Disability and Ataxia: Genetic Collisions
Author/Authors
Kazeminasab, Somayeh University of Social Welfare and Rehabilitation Sciences, Tehran , Najmabadi, Hossein University of Social Welfare and Rehabilitation Sciences, Tehran , Kahrizi, Kimia University of Social Welfare and Rehabilitation Sciences, Tehran
Pages
12
From page
29
To page
40
Abstract
Intellectual disability (ID) is a common and highly heterogeneous neurodevelopmental disorder. The prevalence of ID is around 1%–3% in the general population. ID is associated with a wide range of additional neurological disabilities and the results of various studies have disclosed the co-morbidity of ID and ataxia. The aim of this review is elucidation of the common molecular and cellular pathways in the etiology of ID and ataxia. Categorization of these genes with various cellular functions indicates several genetic collisions in the co-occurrence of ID and ataxia.
Keywords
Ataxia , Ciliogenesis , Ion channels , Intellectual disability , Mitochondria
Journal title
Astroparticle Physics
Serial Year
2018
Record number
2446149
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