Other language title :
ﺑﻲﺣﺴﻲ اﭘﻴﺪورال ﺧﻠﻔﻲ ﻣﺘﻌﺎﻗﺐ ﺗﺰرﻳﻖ ﺗﻨﻬﺎي داروﻫﺎي ﻟﻴﺪوﻛﺎﻳﻴﻦ و ﺗﺮﻛﻴﺐ آن ﺑﺎ ﺗﺮاﻣﺎدول در ﺷﺘﺮ ﺗﻚﻛﻮﻫﺎﻧﻪ
Title of article :
Caudal Epidural Analgesia Using Lidocaine Alone and in Combination with Tramadol in Dromedary Camels
Author/Authors :
Azari, Omid Department of Clinical Sciences - Faculty of Veterinary Medicine - Shahid Bahonar University of Kerman , Molaei, Mohammad Mahdi Department of Clinical Sciences - Faculty of Veterinary Medicine - Shahid Bahonar University of Kerman , Roshani, Hamid Faculty of Veterinary Medicine - Shahid Bahonar University of Kerman
Abstract :
Objective- This study was performed to investigate the analgesic effects of lidocaine and
lidocaine/tramadol combination in epidural anaesthesia in dromedary camels.
Design- Experimental Study
Animals- Eight healthy immature dromedary camels
Procedures- The camels were randomly designed in 2 equal groups. In group L: lidocaine 2% (0.22
mg/kg) and in group LT: a combination of lidocaine 2% (0.22 mg/kg) and tramadol (1 mg/kg) were
injected into the first inter-coccygeal (Co1–Co2) epidural space. Onset time and duration of caudal
analgesia, sedation and ataxia levels were recorded after drug administration.
Results- Epidural lidocaine and co-administration of lidocaine and tramadol produced complete analgesia
in the tail, anus and perineum. There were no significant differences in onset and duration of caudal
analgesia parameters between groups L and LT (p>0.05). Epidural administration of the lidocaine–
tramadol combination resulted in mild to moderate sedation, whilst the animals that received epidural
lidocaine alone were alert and nervous during the study. Ataxia was observed in all test subjects and was
slightly more severe in camels that received the lidocaine–tramadol mixture.
Conclusion and Clinical Relevance- It was concluded that epidural administration of lidocaine plus
tramadol resulted in sedation and unnoticeable longer caudal analgesia in standing conscious dromedary
camels compared with the effect of administering lidocaine alone.
Farsi abstract :
ﻫﺪف- ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ ﺑﻪ ﻣﻨﻈﻮر ﺑﺮرﺳﻲ اﺛﺮات ب دردي ﻧﺎﺷﻲ از ﺗﺰرﻳﻖ اﭘﻴﺪورال داروﻫﺎي ﻟﻴﺪوﻛﺎﻳﻴﻦ و ﺗﺮﻛﻴﺐ ن ﺑﺎ ﺗﺮاﻣﺎدول در ﺷﺘﺮ ﺗﻚ-ﻛﻮﻫﺎﻧﻪ اﻧﺠﺎم ﺷﺪ.
ﻃﺮح ﻣﻄﺎﻟﻌﻪ- ﻣﻄﺎﻟﻌﻪ ﺗﺠﺮﺑﻲ ﺑﺮ روي ﻣﻮﺟﻮد زﻧﺪه.
ﺣﻴﻮاﻧﺎت- ﺗﻌﺪاد 8 ﻧﻔﺮ ﺷﺘﺮ ﺗﻚﻛﻮﻫﺎﻧﻪ ﻧﺎﺑﺎﻟﻎ و ﺳﺎﻟﻢ.
روش ﻛﺎر- در اﻳﻦ ﻣﻄﺎﻟﻌﻪ ﺣﻴﻮاﻧﺎت ﺑﻄﻮر ﺗﺼﺎدﻓﻲ ﺑﻪ2 ﮔﺮوه ﻣﺴﺎوي ﺗﻘﺴﻴﻢ ﺷﺪﻧﺪ. در ﮔﺮوه L: ﻟﻴـﺪوﻛﺎﻳﻴﻦ ﺑـﺎ دوز0/22 ﻣﻴﻠﻴﮕـﺮم ﺑـﻪ ازاي ﻛﻴﻠﻮﮔﺮم وزن ﺑﺪن و در ﮔﺮوه LT ﺗﺮﻛﻴﺐ داروﻫﺎي ﺗﺮاﻣﺎدول ﺑﺎ دوز 1 ﻣﻴﻠﻲﮔﺮم ﺑﻪ ازاي ﻛﻴﻠﻮﮔﺮم وزن ﺑﺪن و ﻟﻴـﺪوﻛﺎﻳﻴﻦ ﺑـﺎ دوز ﻣـﺬﻛﻮر، در اوﻟﻴﻦ ﻓﻀﺎي ﺑﻴﻦ ﻣﻬﺮهاي دم ﺗﺰرﻳﻖ ﺷﺪ. زﻣﺎن ﺷﺮوع و ﻃﻮل ﻣﺪت ﺑﻲدردي، ﺷﺪت آرامﺑﺨﺸﻲ و ﻋﺪم ﺗﻌﺎدل ﺑﻌﺪ از ﺗﺰرﻳﻖ اﭘﻴـﺪورال داروﻫـﺎي ﻣﺬﻛﻮر ﺛﺒﺖ ﮔﺮدﻳﺪ و ﺑﻴﻦ ﮔﺮوهﻫﺎ ﻣﻮرد ﻣﻘﺎﻳﺴﻪ ﮔﺮﻓﺖ.
ﻧﺘﺎﻳﺞ- ﻧﺘﺎﻳﺞ اﻳﻦ ﺑﺮرﺳﻲ ﻧﺸﺎن داد ﻛﻪ ﺗﺰرﻳﻖ اﭘﻴﺪورال داروﻫﺎي ﻟﻴﺪوﻛﺎﻳﻴﻦ و ﺗﺮﻛﻴﺐ آن ﺑﺎ ﺗﺮاﻣـﺎدول ﺳـﺒﺐ اﻟﻘـﺎي ﺑـﻲ دردي در ﻧﺎﺣﻴـﻪ دم،ﻣﻘﻌﺪ و ﭘﺮﻳﻨﻪ ﮔﺮدﻳﺪ. ارزﻳﺎﺑﻲ دادهﻫﺎ ﻧﺸﺎن داد ﻛﻪ زﻣﺎن ﺷﺮوع ﺑﻲدردي و ﻃﻮل ﻣﺪت آن ﺑـﻴﻦ دو ﮔـﺮوه ﻣـﻮرد ﻣﻄﺎﻟﻌـﻪ ﺗﻔـﺎوت ﻣﻌﻨـﻲ داري ﻧﺪاﺷﺘﻨﺪ )P>0.05(. در ﻃﻮل دوره ﻣﻄﺎﻟﻌﻪ آراﻣﺒﺨﺸﻲ ﺧﻔﻴﻒ ﺗﺎ ﺣﺪ ﻣﺘﻮﺳﻂ در ﮔﺮوه LTدﻳﺪه ﺷﺪ، اﻣﺎ در ﮔﺮوه L ﺣﻴﻮاﻧﺎت ﻛﺎﻣﻼ" ﻫﻮﺷﻴﺎر و ﻋﺼﺒﻲ ﺑﻮدﻧﺪ. ﻋﻼﺋﻢ ﻋﺪم ﺗﻌﺎدل ﻣﺘﻌﺎﻗﺐ ﺗﺰرﻳﻖ اﭘﻴﺪورال دارو در ﺗﻤﺎم ﺣﻴﻮاﻧﺎت ﮔﺮوﻫﻬﺎي L و LT ﻣﺸﺎﻫﺪه ﺷﺪ، در ﺣﺎﻟﻴﻜﻪ ﻋـﺪم ﺗﻌـﺎدل در ﺣﻴﻮاﻧﺎت ﮔﺮوه LT ﺷﺪﻳﺪﺗﺮ ﺑﻮد.
ﻧﺘﻴﺠﻪﮔﻴﺮي و ﻛﺎرﺑﺮد ﺑﺎﻟﻴﻨﻲ- ﺑﺮ ﭘﺎﻳﻪ ﻧﺘﺎﻳﺞ ﺣﺎﺻﻠﻪ ﻣﻴﺘﻮان اﻳﻨﮕﻮﻧﻪ ﻧﺘﻴﺠﻪﮔﻴﺮي ﻧﻤﻮد ﻛﻪ ﺗﺰرﻳﻖ اﭘﻴـﺪورال ﺗﺮﻛﻴـﺐ داروﻫـﺎي ﻟﻴـﺪوﻛﺎﻳﻴﻦ و ﺗﺮاﻣﺎول ﺳﺒﺐ اﻓﺰاﻳﺶ ﻣﻌﻨﻲدار در ﻃﻮل ﻣﺪت ﺑﻲدردي ﺧﻠﻔﻲ ﻧﺴﺒﺖ ﺑﻪ ﺗﺰرﻳﻖ ﺗﻨﻬﺎي ﻟﻴﺪوﻛﺎﻳﻴﻦ ﻧﮕﺮدﻳﺪ، اﮔﺮﭼﻪ ﺗﺮﻛﻴﺐ ﻓـﻮق ﺳـﺒﺐ اﻳﺠـﺎد ﻋﻼﺋﻢ آرامﺑﺨﺸﻲ در ﺷﺘﺮ ﺗﻚﻛﻮﻫﺎﻧﻪ ﻣﻲﮔﺮدد.
Keywords :
Epidural , Lidocaine , Tramadol , Dromedary camels
Journal title :
Astroparticle Physics